In Stock

Guardian One® 410mg Lufenuron & Nitenpyram monthly for Large Dogs 46.1 - 91 Lbs

2 reviews Write a Review
$39.95 - $379.95
Guardian One® 410mg Lufenuron & Nitenpyram monthly for Large Dogs 46.1 - 91 Lbs
Guardian One® 410mg Lufenuron & Nitenpyram monthly for Large Dogs 46.1 - 91 Lbs
Minimum Purchase:
1 unit
Current Stock:

Frequently Bought Together:

Guardian One® 410mg Lufenuron & Nitenpyram monthly for Large Dogs 46.1 - 91 Lbs
Inc. Tax
Ex. Tax


Pet owners love Guardian products for a reason!

  • 57mg of Nitenpyram and 410mg of USP grade Lufenuron carefully blended with premium meat in a compact clear gelcap
  • For Large Dogs 46.1 - 91 Lbs
  • Nitenpyram starts working in 30 minutes and Lufenuron protects for 30 days
  • Guardian One is given once every 30 days and is an excellent monthly pet product
  • No Preservatives and No Artificial Flavors
  • 2 All Natural, Real Smoked Meats 
  • Lufenuron and Nitenpyram have been available in Canada and the USA since 1995, and are currently marketed in over 30 countries worldwide.
  • A must have product for spring and summer!
  • An easy to use gelcap makes our products super flexible to give, even for the most resistant pet!
  • Nitenpyram is the gold standard in pet supply products. 
  • Lufenuron and Nitenpyram are both gentle and time tested.
  • We never want price to a be a barrier between pet's getting the products that make their lives better. 

Expiration date:

Guardian ONLY uses all natural, restaurant quality cuts of meat in their products. Guardian products contain no preservatives and we only use oak or hickory fired smoke to preserve our dried meats. They can last almost indefinitely refrigerated and 2 years or longer in a room temperature drawer. The airtight bottle cap and gelcaps locking design reduce air penetration dramatically compared to tablets and soft chews.


  • Guardian One with Lufenuron + Nitenpyram should be given once a month.
  • This product may be given as often as needed following the initial monthly dose.
  • Guardian One with Lufenuron + Nitenpyram should NOT be given to dogs with a history of seizures or kidney problems.
  • This product should be given on a full stomach to ensure optimal absorption of Lufenuron.
  • The Lufenuron and Nitenpyram in this product is for all healthy dogs and puppies weighing between 46.1 and 91 pounds and over 8 weeks of age.
  • This product can be used with pregnant or nursing dogs.
  • The gelcap separates the Lufenuron and Nitenpyram from your dog's taste buds and scent receptors and also helps avoid the bitter reaction common in many pet medications and supplements on the market in tablet or chewable form.
  • If you're not sure that your dog or cat consumed the pill or it's contents, you may give another pill.
  • The gelcap delivery method gives you a more flexible feeding window. The gelcap will delay the release of the Lufenuron by a few minutes compared to a tablet or chew.
  • Our gelcap products benefit from our Flavor Infusion technology. We infuse the outer gelcap wall with the scent of the meat inside. It's a delicate process and requires a proprietary manufacturing method. This does NOT flavor the gelcap, it only adds scent for ultra-discerning pets.
  • Guardian's Gelcap products are designed to make it easy to use even with super finicky pets!
  • Guardian's gelcap products are designed to make your life and your pet's life much better. Your pets deserve to live in a utopia! We hope you'll never dread spring and summer again!

Product Reviews (2)

  • 5

    love it

    works awesome. kills fleas fast!

  • 5

    Luv em

    Luv this for my dogs. I live in the south this works. Hard to find something that I dont have to go to a vet. for. When they itch I give them a pill.